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Test, don't guess!

Let Proov Help your Patients at Home
Proov is the first and only FDA-Cleared Progesterone Test system to confirm ovulation at home and show the needed rise in PdG over multiple days to support healthy conception. Proov test system provides clinicians an additional data point to help assess fertility issues related to anovulation, recurrent first trimester miscarriage, and high risk early pregnancy.

Empower more informed virtual treatment with FDA-cleared Proov test.


How Proov Works

Tracks PdG

Pregnanediol Glucuronide
(PdG) is the urine metabolite of progesterone

Multiple Days of Testing

Proov measures pregnanediol glucuronide (PdG) in first morning urine 7-10 days past ovulation

Data is Power

Testing over multiple days confirms if PdG levels are high enough to support healthy conception. Proov strips turn positive at 5 ug/ml of PdG in urine, which correlates to ~10 ng/ml in serum.

Digital Interface

Proov testing is done at home and results are communicated via the free Proov app or photos

Clinical Uses of Proov

Proov is most effective when used 7-10 dpo. Studies show PdG levels are high during this testing window in proven fertile women and act to enable proper implantation.

One Proov 7-Strip Kit Can:

Confirm ovulation

Diagnose luteal phase defect

Diagnose cause of recurrent miscarriage

Proov Works for Women With:

Polycystic Ovarian Syndrome (PCOS)


History of first trimester misscarriage

maternal age

Low Ovarian

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Device Validation Studies

1 Alliende 2018

• Proov has been clinically validated in 2 independent studies (Leiva 2019, Bouchard 2019).

• A laboratory study has shown this test to be over 99% accurate in detecting PdG in urine. The sensitivity of Proov is 5 ug/ml PdG.

• The lateral flow test strips are stable at 4-30° (39-86F) for 24 months based on the accelerated stability study at 42°.

• Devices showed no interference to common urine compounds such as: LH, HCG, Estone-3-Glucuronide, Acetaminophen, Ascorbic Acid, Caffeine, Glucose, Ampicillin, Ketone, Acetylsalicylic Acid, Atropine, Gentisic Acid, Hemoglobin, Tetracycline, Nitrites, Phenothiazine, Ethanol, and Albumin.

• Specific gravity or urine and urine pH don't affect device accuracy.

• Proov was compared to laboratory PdG EIA tests and shown only to be positive when PdG was >5ug/ml.

• A lay user study was conducted in 101 women and results demonstrate 99% of women can correctly read Proov results and 92% of women said device instructions and testing were easy or very easy.