A link between PdG and pregnancy

High PdG levels could indicate a successful pregnancy

We came across a couple interesting articles looking at the link between elevated PdG levels and pregnancy outcome. The data suggest that in a successful pregnancy, PdG levels remain elevated, as seen below. However, PdG levels declined in the late luteal phase of non-conception cycles and when early pregnancy loss occurred. Furthermore, they also show that elevated PdG levels could be used as a possible diagnostic tool for early pregnancy. Currently, early pregnancy health is measured as a function of hCG doubling time. The authors suggest that high PdG levels in early pregnancy could be a more accurate measure. While this research is very exciting, we don’t know if Proov tests can be used as an early pregnancy diagnostic. However, in a near future, we hope to conduct our own research studies to help answer this important question.


S Venners et al, “Urinary estrogen and progesterone metabolite concentrations in menstrual cycles of fertile women with non-conception, early pregnancy loss or clinical pregnancy” Human Reproduction Vol.21, No.9 pp. 2272–2280, 2006.
CA Long et al. “First-trimester rapid semiquantitative assay for urine pregnanediol glucuronide predicts gestational outcome with the same diagnostic accuracy as serial human chorionic gonadotropin measurements.” American journal of obstetrics and gynecology Vol 170. No.6 pp. 1822-5, 1994.